Over the last thirty-plus years, liver cancer death rates have dramatically increased in the U.S., with the disease now ranking as the fastest-rising cancer fatality as over 40,000 new cases and almost 30,000 deaths are projected in 2017. Unfortunately, the liver cancer mortality rate is one in five, although the disease is preventable, particularly among the baby boomer generation who may be more susceptible given their elevated risk for hepatitis, a major contributor to liver cancer. It is recommended that baby boomers undergo at least once hepatitis screening, and hepatitis B vaccinations are available, as are hepatitis C medications that can prevent liver cirrhosis and conditions that can lead to liver cancer. Excess weight, diabetes, and alcohol consumption are also risk factors for liver cancer and are important prevention factors.