Increasingly, the benefits of central neuromodulators (antidepressants, antipsychotics, and other targeted drugs) in treating functional GI disorders (FGIDs) that are accompanied by chronic pain and pronounced symptoms, such as irritable bowel syndrome (IBS), are becoming more apparent. Unfortunately, many physicians are less familiar with these more recent forms of treatment, which often leads to patients being less informed about these methods as alternatives to reducing frequent abdominal pain and other symptoms. One type of these medications, antidepressants, utilize our gut-brain interactions to help alleviate functional GI disorder issues.